Protein S Deficiency with Favourable Foetomaternal Outcome: A Case Report
Published: February 1, 2023 | DOI: https://doi.org/10.7860/JCDR/2023/57874.17492
Swati Sugandha, Shivanshi Sharma, Monika Jindal, Santosh Minhas
1. Assistant Professor, Department of Obstetrics and Gynaecology, Maharishi Markandeshwar Medical College and Hospital, Solan, Kumarhatti, Himachal Pradesh, India.
2. Postgraduate Resident, Department of Obstetrics and Gynaecology, Maharishi Markandeshwar Medical College and Hospital, Solan, Kumarhatti, Himachal Pradesh, India.
3. Professor, Department of Obstetrics and Gynaecology, Maharishi Markandeshwar Medical College and Hospital, Solan, Kumarhatti, Himachal Pradesh, India.
4. Professor, Department of Obstetrics and Gynaecology, Maharishi Markandeshwar Medical College and Hospital, Solan, Kumarhatti, Himachal Pradesh, India.
Correspondence
Swati Sugandha,
House No. B-503, MMMCH Campus, Kumarhatti, Solan, Himachal Pradesh, India.
E-mail: swati.sugandha90@gmail.com
Protein S is a multifunctional plasma protein, whose deficiency, results in a rare congenital thrombophilia, inherited in an autosomal dominant pattern. It can aggravate the hypercoagulable state of pregnancy, when it presents in parallel with the condition, leading to adverse maternal outcomes and foetal loss. A 35-year-old female third gravida having previous 2 deliveries by Lower Segment Caesarean Section (LSCS) presented to emergency at 10 weeks pregnancy with chief complaints of pain and swelling in left thigh since 4-5 days. After thorough investigations and work-up, the patient was diagnosed with Protein S deficiency. She was managed conservatively and was delivered by elective LSCS with bilateral tubal ligation at 38 weeks of gestation with good foetal and maternal outcomes.The rarity of Protein S deficiency along with the successful outcome of the pregnancy makes this a unique case.
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